Coronavirus Disease 2019 (COVID-19): The Disease & Its Spread (Per Se)

EnolaGaia

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Both these two newly published reports on randomized clinical studies (one from France; the other from China) fail to provide any support for the notion that hydroxychloroquine provides any substantial benefit to COVID-19 patients.
Results From Randomized Clinical Trial Do Not Support Hydroxychloroquine for COVID-19

The anti-inflammatory drug hydroxychloroquine does not significantly reduce admission to intensive care or death in patients hospitalized with pneumonia due to covid-19, finds a study from France published by The BMJ on May 14, 2020.

A randomized clinical trial from China also published on May 14, 2020, shows that hospitalized patients with mild to moderate persistent covid-19 who received hydroxychloroquine did not clear the virus more quickly than those receiving standard care. Adverse events were higher in those who received hydroxychloroquine.

Taken together, the results do not support routine use of hydroxychloroquine for patients with covid-19. ...

For more details see:

FULL STORY: https://scitechdaily.com/results-fr...-not-support-hydroxychloroquine-for-covid-19/

PUBLISHED REPORT (French Study):
https://www.bmj.com/content/369/bmj.m1844

PUBLISHED REPORT (Chinese Study):
https://www.bmj.com/content/369/bmj.m1849
 

EnolaGaia

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This anecdotal study from Florida has a sample size of only two, but it seems to clearly indicate scoffing at medical advice, ignoring safety measures, and trusting in God alone are no match for the COVID-19 virus.
Jupiter man skeptical of coronavirus gets infected, changes opinion

Patient urges encourages people to take virus seriously

A Jupiter man, who admits he was skeptical that the coronavirus was a real threat, has a new outlook after contracting the virus.

Around this time last month, Jupiter rideshare driver Brian Hitchens was a self-proclaimed COVID-19 skeptic.

“I thought it was maybe the government trying something, and it was kind of like they threw it out there to kinda distract us,” said Hitchens.

He made Facebook posts downplaying the seriousness and sticking to his faith, saying God is bigger than this virus will ever be.

“I'd get up in the morning and pray and trust in God for his protection, and I’d just leave it at that. There were all these masks and gloves. I thought it looks like a hysteria,” Hitchens explained.

Fast forward to this week and Hitchens has a whole new outlook from his hospital bed at Palm Beach Gardens Medical Center as a coronavirus-positive patient.

"I don’t want to see anyone go through what I went through," Hitchens said. ...

He recently took to social media about his experience, now encouraging people to take the virus seriously.

“This wasn’t some scare tactic that anybody was using. It wasn’t some made-up thing. This was a real virus you gotta take seriously,” Hitchens said.

This hits even closer to home for Hitchens after his wife was admitted to the same hospital at the same time for coronavirus.

"My wife’s on a ventilator. It’s been like that for three weeks, and it’s tough. It’s sad,” said Hitchens. ...

FULL STORY:
https://www.wptv.com/news/coronavir...-of-coronavirus-gets-infected-changes-opinion

See Also:
https://www.patheos.com/blogs/thefr...l-says-man-who-claimed-god-would-protect-him/
 

Ogdred Weary

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Mythopoeika

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Using sniffer dogs to find people with Covid-19:
One problem - might the dogs catch it as well?
 

blessmycottonsocks

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Mythopoeika

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Trevp666

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As usual, later on this afternoon I will be producing my daily update to the NHS England statistics.
I'm considering stopping posting this info though as I'm not sure if anyone seems really that interested in it?
Also the numbers are getting so low now that it hardly seems worth it.
Unless the 'second peak' comes along, but IMO that's unlikely.
Also, tomorrow I will be unlikely to produce the daily update until much later as I am returning (in a limited capacity) to work.
If anyone still finds value in the daily updates beyond today then let me know.
 

Trevp666

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Todays (17/5/20) NHS England 'new deaths' figures released.
(It's getting very low now!)

https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-daily-deaths/

Todays figures and notable statistics;
90 reported 'new' deaths today;
Daily actual totals now reaching the point of dropping below 100 per day
167 of the 202 trusts today reported 0 new deaths (That's 83%)
For the 3rd day, no trust reported more than 10 deaths (highest amount is 7).
No single trust stands out as reporting a greater number than any other.

There are no deaths which are over a week old.
The oldest reported 'new' deaths are 2 from different sites, on this last Tuesday, May 12th

Todays deaths by age group;
0-19 = 0
20-39 = 0
40-59 = 8
60-78 = 31
80+ = 51

We are well beyond the 'peak' now, which occurred around the 4th - 8th April.
Saturday this week (yesterday) showing 33 - however, as the daily figure is communicated to NHS England at 5pm each day the total for the whole of yesterday is not complete.

Below I show my running totals for;
Existing deaths + New deaths = New totals (If no 'new' to add then no calculation has been entered)
(since Thursday April 2nd, the date I started logging the numbers officially released).

T 811
F 615
S 1107 (Saturday April 4th)
S 1094
M 940
T 808
W 889
T 778
F 734
S 770 (April 11th)
S 714
M 689
T 643
W 682
T 631
F 604
S 567 (April 18th)
S 518
M 556
T 479
W 486
T 445
F 431
S 385 (April 25th)
S 373
M 339
T 338
W 319
T 301
F 299
S 263 (May 2nd)
S 243
M 246
T 243
W 246
T 239
F 195
S 188 (May 9th)
S 183
M 152
T 168+2=170
W 135+5=140
T 134+4=138
F 39+46=85
S -----------33

(Figures supplied by NHS England date back to the beginning of March when the UK recorded it's first day with more than 50 deaths.
The figures released daily include deaths from the day on which they happened, so can be from any previous day NOT from just within the past 24 hours)
 

Lb8535

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Using sniffer dogs to find people with Covid-19:
One problem - might the dogs catch it as well?
So far, it has been contagious only to a few cats, one dog in Europe tested positive. Given the number of people with housepets who have been infected, it seems a tiny possibility. Of course dogs could catch it and be carriers, as we have not been testing dogs. I suspect the program managers have thought this through.
 

EnolaGaia

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Meanwhile ... Russia is grappling with its seemingly belated "first wave" COVID-19 problems. There are controversies over reported statistics and the vulnerable state of medical infrastructures anywhere other than Moscow.

Here are some of the top-level points ... More details can be accessed via the link.

Coronavirus has devastated Moscow. Now it's spreading across Russia's 11 time zones to ill-funded regions

Russia hit a grim Covid-19 milestone this week: According to Johns Hopkins University, the country now ranks second in the world for confirmed coronavirus cases.

The Russian capital has been hardest hit. Of Russia's total of 281,752 confirmed cases, over half -- 142,824 -- are in Moscow, the country's coronavirus headquarters said Sunday. But the virus is now spreading across Russia's regions, an enormous landmass that covers 11 time zones and includes some of the country's most remote and impoverished places. ...

According to official statistics, the pandemic has reached all of Russia's constituent parts, from the Kaliningrad exclave between Poland and Lithuania to the remote Chukotka autonomous okrug, across the Bering Strait from Alaska. Russia's regions are also starting to report their own numbers, sometimes showing a disparity between the nationally published statistics on mortality and infections published on the stopcoronavirus.rf portal and on local government websites. ...

Russian Vice-Premier Tatiana Golikova told Russian news outlets this week that the Russian government has not manipulated statistics, but Russia's mortality figures have become a political football. ...

In Moscow, health officials hit back at media reports that it was underreporting Covid-19 fatalities, saying its data was "absolutely open." But the city's health department also acknowledged that it only counts deaths that were found through post-mortem autopsy to have been caused directly by coronavirus complications. ...

FULL STORY: https://www.cnn.com/2020/05/17/europe/russia-coronavirus-time-zones-intl/index.html
 

uair01

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ThosRandomBloke

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As usual, later on this afternoon I will be producing my daily update to the NHS England statistics.
I'm considering stopping posting this info though as I'm not sure if anyone seems really that interested in it?
Also the numbers are getting so low now that it hardly seems worth it.
Unless the 'second peak' comes along, but IMO that's unlikely.
Also, tomorrow I will be unlikely to produce the daily update until much later as I am returning (in a limited capacity) to work.
If anyone still finds value in the daily updates beyond today then let me know.

I’ve found your updates really helpful and interesting though, clearly, I understand that you may no longer have time to keep doing them.
 

fizzy55

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As usual, later on this afternoon I will be producing my daily update to the NHS England statistics.
I'm considering stopping posting this info though as I'm not sure if anyone seems really that interested in it?
Also the numbers are getting so low now that it hardly seems worth it.
Unless the 'second peak' comes along, but IMO that's unlikely.
Also, tomorrow I will be unlikely to produce the daily update until much later as I am returning (in a limited capacity) to work.
If anyone still finds value in the daily updates beyond today then let me know.
I'm interested Trev! Your posts have definitely helped me to keep things in perspective over the last 7 or so weeks. I do understand though, if you no longer have the time. Thank you for taking the time to do them as long as you have been able to. :)
 

Analogue Boy

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As usual, later on this afternoon I will be producing my daily update to the NHS England statistics.
I'm considering stopping posting this info though as I'm not sure if anyone seems really that interested in it?
Also the numbers are getting so low now that it hardly seems worth it.
Unless the 'second peak' comes along, but IMO that's unlikely.
Also, tomorrow I will be unlikely to produce the daily update until much later as I am returning (in a limited capacity) to work.
If anyone still finds value in the daily updates beyond today then let me know.

Jesus. I haven't stopped working. if anything, I've been working hard than I usually do at work.

Thanks SHIT internet.
 

EnolaGaia

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This newly published research could prove to be quite significant ... Micro-RNAs (miRNAs) in a host's cells often serve as the initial line of defense against pathogens. It appears that multiple of the miRNAs that target and nullify the COVID-19 virus are among the miRNAs which are naturally diminished as we age or are afflicted with the sort of "underlying conditions" mentioned as COVID-19 risk factors. This explains why patients who are older and / or have such underlying conditions have an increased mortality rate.
Tiny RNA That Should Attack COVID-19 Coronavirus Diminish With Age, Disease

A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report.

MicroRNAs play a big role in our body in controlling gene expression, and also are a front line when viruses invade, latching onto and cutting the RNA, the genetic material of the virus, says Dr. Sadanand Fulzele, aging researcher in the Department of Medicine and Center for Healthy Aging at the Medical College of Georgia at Augusta University.

But with age and some chronic medical conditions, the attacking microRNA numbers dwindle, reducing our ability to respond to viruses, says Dr. Carlos M. Isales, co-director of the MCG Center for Healthy Aging and chief of the MCG Division of Endocrinology, Diabetes and Metabolism.

Much like not having enough troops on the ground in an actual war, the coronavirus is then better able to do what it does naturally, which is hijack our cell machinery so it can replicate, say the researchers who report in the journal Aging and Disease what appear to be key microRNA involved in responding to this virus. They have a longer-term goal of identifying the biggest hitters and replenishing those troops. ...

FULL STORY: https://scitechdaily.com/tiny-rna-that-should-attack-covid-19-coronavirus-diminish-with-age-disease/
 

EnolaGaia

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Here are the bibliographic particulars and abstract for the miRNA research article cited above.

Fulzele Sadanand,Sahay Bikash,Yusufu Ibrahim, et al.
COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile.
Aging and disease, 2020, 11(3): 509-522.
Abstract
The World health organization (WHO) declared Coronavirus disease 2019 (COVID-19) a global pandemic and a severe public health crisis. Drastic measures to combat COVID-19 are warranted due to its contagiousness and higher mortality rates, specifically in the aged patient population. At the current stage, due to the lack of effective treatment strategies for COVID-19 innovative approaches need to be considered. It is well known that host cellular miRNAs can directly target both viral 3'UTR and coding region of the viral genome to induce the antiviral effect. In this study, we did in silico analysis of human miRNAs targeting SARS (4 isolates) and COVID-19 (29 recent isolates from different regions) genome and correlated our findings with aging and underlying conditions. We found 848 common miRNAs targeting the SARS genome and 873 common microRNAs targeting the COVID-19 genome. Out of a total of 848 miRNAs from SARS, only 558 commonly present in all COVID-19 isolates. Interestingly, 315 miRNAs are unique for COVID-19 isolates and 290 miRNAs unique to SARS. We also noted that out of 29 COVID-19 isolates, 19 isolates have identical miRNA targets. The COVID-19 isolates, Netherland (EPI_ISL_422601), Australia (EPI_ISL_413214), and Wuhan (EPI_ISL_403931) showed six, four, and four unique miRNAs targets, respectively. Furthermore, GO, and KEGG pathway analysis showed that COVID-19 targeting human miRNAs involved in various age-related signaling and diseases. Recent studies also suggested that some of the human miRNAs targeting COVID-19 decreased with aging and underlying conditions. GO and KEGG identified impaired signaling pathway may be due to low abundance miRNA which might be one of the contributing factors for the increasing severity and mortality in aged individuals and with other underlying conditions. Further, in vitro and in vivo studies are needed to validate some of these targets and identify potential therapeutic targets.
SOURCE: http://www.aginganddisease.org/EN/10.14336/AD.2020.0428
 

Naughty_Felid

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Here are the bibliographic particulars and abstract for the miRNA research article cited above.

Fulzele Sadanand,Sahay Bikash,Yusufu Ibrahim, et al.
COVID-19 Virulence in Aged Patients Might Be Impacted by the Host Cellular MicroRNAs Abundance/Profile.
Aging and disease, 2020, 11(3): 509-522.

SOURCE: http://www.aginganddisease.org/EN/10.14336/AD.2020.0428

Thanks, EG I've really appreciated the quality of links you've posted during this crisis. Seriously.
 

maximus otter

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Up to 20% of hospital patients in England got coronavirus while in for another illness

Up to a fifth of patients with Covid-19 in several hospitals contracted the disease over the course of the pandemic while already being treated there for another illness, NHS bosses have told senior doctors and nurses.

Some of the infections were passed on by hospital staff who were unaware they had the virus and were displaying no symptoms, while patients with coronavirus were responsible for the others.

https://www.theguardian.com/world/2...england-coronavirus-covid-19?CMP=share_btn_tw

maximus otter
 

Robbrent

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Todays (17/5/20) NHS England 'new deaths' figures released.
(It's getting very low now!)

https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-daily-deaths/

Todays figures and notable statistics;
90 reported 'new' deaths today;
Daily actual totals now reaching the point of dropping below 100 per day
167 of the 202 trusts today reported 0 new deaths (That's 83%)
For the 3rd day, no trust reported more than 10 deaths (highest amount is 7).
No single trust stands out as reporting a greater number than any other.

There are no deaths which are over a week old.
The oldest reported 'new' deaths are 2 from different sites, on this last Tuesday, May 12th

Todays deaths by age group;
0-19 = 0
20-39 = 0
40-59 = 8
60-78 = 31
80+ = 51

We are well beyond the 'peak' now, which occurred around the 4th - 8th April.
Saturday this week (yesterday) showing 33 - however, as the daily figure is communicated to NHS England at 5pm each day the total for the whole of yesterday is not complete.

Below I show my running totals for;
Existing deaths + New deaths = New totals (If no 'new' to add then no calculation has been entered)
(since Thursday April 2nd, the date I started logging the numbers officially released).

T 811
F 615
S 1107 (Saturday April 4th)
S 1094
M 940
T 808
W 889
T 778
F 734
S 770 (April 11th)
S 714
M 689
T 643
W 682
T 631
F 604
S 567 (April 18th)
S 518
M 556
T 479
W 486
T 445
F 431
S 385 (April 25th)
S 373
M 339
T 338
W 319
T 301
F 299
S 263 (May 2nd)
S 243
M 246
T 243
W 246
T 239
F 195
S 188 (May 9th)
S 183
M 152
T 168+2=170
W 135+5=140
T 134+4=138
F 39+46=85
S -----------33

(Figures supplied by NHS England date back to the beginning of March when the UK recorded it's first day with more than 50 deaths.
The figures released daily include deaths from the day on which they happened, so can be from any previous day NOT from just within the past 24 hours)
They were low because the system for reporting was down for over 18 hours all over the UK, expect a significant bounce sometime this week
 

Trevp666

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No, you won't get a 'bounce sometime this week' because (as I have explained more than once to different people), the NHS figures give the DATE THE DEATH HAPPENED, it is not (e.g.) "Today is Monday and here is the deaths......37".
So assuming that the reporting system was down for a period of time then all that will happen is that some of the missing info across the past few days will fill in some gaps. We aren't saying to people "Dont die just yet.....our system's down".
 

ramonmercado

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Things are bleak in Brazil.

The mayor of Brazil's largest city, São Paulo, has said its health system could collapse as demand grows for emergency beds to deal with coronavirus cases.

Bruno Covas said the city's public hospitals had reached 90% capacity and could run out of space in two weeks. He accused those who flouted lockdown rules of playing "Russian roulette" with people's lives. São Paulo is one of the country's worst-hit regions, with almost 3,000 deaths so far.

Brazil's far-right president Jair Bolsonaro has been strongly criticised both at home and abroad for his handling of the country's escalating coronavirus crisis. He defied global health advice on social distancing on Sunday when he posed for photographs with supporters and children in the capital, Brasília.

On Saturday, Brazil overtook Spain and Italy to become the country with the fourth-largest number of infections.

https://www.bbc.com/news/world-latin-america-52701524
 

Trevp666

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Todays (18/5/20) NHS England 'new deaths' figures released.

https://www.england.nhs.uk/statistics/statistical-work-areas/covid-19-daily-deaths/

Todays figures and notable statistics;
122 reported 'new' deaths today;
Daily actual totals now dropping below 100 per day
155 of the 202 trusts today reported 0 new deaths (That's 77%)
For the 4th day, no trust reported more than 10 deaths (highest amount is 7).
No single trust stands out as reporting a greater number than any other.

There are no deaths which are over a week old.
The oldest reported 'new' death is one from May 13th from Kings Lynn.

Todays deaths by age group;
0-19 = 0
20-39 = 0
40-59 = 11
60-78 = 45
80+ = 66

We are well beyond the 'peak' now, which occurred around the 4th - 8th April.
Sunday this week (yesterday) showing 27 - however, as the daily figure is communicated to NHS England at 5pm each day the total for the whole of yesterday is not complete.

Below I show my running totals for;
Existing deaths + New deaths = New totals (If no 'new' to add then no calculation has been entered)
(since Thursday April 2nd, the date I started logging the numbers officially released).

T 811
F 615
S 1107 (Saturday April 4th)
S 1094
M 940
T 808
W 889
T 778
F 734
S 770 (April 11th)
S 714
M 689
T 643
W 682
T 631
F 604
S 567 (April 18th)
S 518
M 556
T 479
W 486
T 445
F 431
S 385 (April 25th)
S 373
M 339
T 338
W 319
T 301
F 299
S 263 (May 2nd)
S 243
M 246
T 243
W 246
T 239
F 195
S 188 (May 9th)
S 183
M 152
T 170
W 140+1=141
T 138+6=144
F 85+29=114
S 33+59=92
S--------------27

(Figures supplied by NHS England date back to the beginning of March when the UK recorded it's first day with more than 50 deaths.
The figures released daily include deaths from the day on which they happened, so can be from any previous day NOT from just within the past 24 hours)
 

Naughty_Felid

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Up to 20% of hospital patients in England got coronavirus while in for another illness

Up to a fifth of patients with Covid-19 in several hospitals contracted the disease over the course of the pandemic while already being treated there for another illness, NHS bosses have told senior doctors and nurses.

Some of the infections were passed on by hospital staff who were unaware they had the virus and were displaying no symptoms, while patients with coronavirus were responsible for the others.

https://www.theguardian.com/world/2...england-coronavirus-covid-19?CMP=share_btn_tw

maximus otter
Shows how dangerous it is. How easily it transmits and throw in the lack of PPE and years of underfunding - no surprise really.

Staying in hospital always has its risks. MRSA has been a problem for years.
 

EnolaGaia

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An antibody present in the blood of someone who'd had SARS in 2003 seems to inhibit COVID-19 as well.
Antibody that inhibits the new coronavirus discovered in patient who had SARS 17 years ago

A person who had severe acute respiratory syndrome (SARS) 17 years ago could help scientists in the search for therapies to fight the new coronavirus, SARS-CoV-2, according to a new study from a biotech company.

The study researchers found that blood samples from this patient, who had SARS in 2003, contained an antibody that also appears to inhibit SARS-CoV-2. ...

This particular antibody, which the researchers call S309, showed a strong ability to bind to and disable the "spike protein" on SARS-CoV-2 that allows the virus to enter cells ...

The findings "pave the way" for using S309, either by itself or as part of an "antibody cocktail," for preventing or treating COVID-19 (the disease caused by the novel coronavirus), the authors wrote in their paper, published today (May 18) in the journal Nature. ...

FULL STORY: https://www.livescience.com/sars-antibody-inhibits-new-coronavirus.html
 
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