La forza del destino by Verdi has a curse - apparently.
From Wikipedia:
Forza is an opera that many old school Italian singers felt was "cursed" and brought bad luck.[11] The very superstitious Luciano Pavarotti avoided the part of Alvaro for this reason.
On 4 March 1960 at the Metropolitan Opera, in a performance of La Forza del Destino with Renata Tebaldi and tenor Richard Tucker, the American baritone Leonard Warren was about to launch into the vigorous cabaletta to Don Carlo's Act 3 aria, which begins "Morir, tremenda cosa" ("to die, a momentous thing"). While Rudolf Bing reports that Warren simply went silent and fell face-forward to the floor,[12] others state that he started coughing and gasping, and that he cried out "Help me, help me!" before falling to the floor, remaining motionless. A few minutes later he was pronounced dead of a massive cerebral hemorrhage, and the rest of the performance was canceled. Warren was only 48.
The "Curse" prompted singers and others to do strange things to fend off possible bad luck. The great Italian tenor Franco Corelli was rumored to have held on to his crotch during some of his performances of the opera as "protection."[13] Anthony Stivanello, a well-known Italian director from the 1950s–1980s who also provided sets and costumes to opera companies nationwide insisted that while he had the scenery and costumes for the opera, he would not touch them himself. "Oh, tu che in seno," the tenor's main aria from the opera, was being sung during a concert in Bergen County, NJ, a number of years ago. As the tenor finished the aria, the lights went out in the theater. The power failure was reportedly blamed on a problem in the cemetery across the street.