Fortea Morgana :) PeteByrdie certificated Princess
- Jul 14, 2014
- Reaction score
- An Eochair
Very kind, thank you- the feeling is mutualI like you, Coastaljames.
... I'd add to that diet requirements but it makes a lot of sense to me so far.Depression: A revolution in treatment?
By James Gallagher, Rachael Buchanan & Andrew Luck-Baker The Inflamed Mind, BBC Radio 4
It's not very often we get to talk about a revolution in understanding and treating depression and yet now doctors are talking about "one of the strongest discoveries in psychiatry for the last 20 years".
It is based around the idea that some people are being betrayed by their fiercest protector. That their immune system is altering their brain.
The illness exacts a heavy toll on 350 million people around the world, among them Hayley Mason, from Cambridgeshire:
"My depression gets so bad that I can't leave the bed, I can't leave the bedroom, I can't go downstairs and be with my partner and his kids.
The 30-year-old added: "I can't have the TV on, I can't have noise and light, I have suicidal thoughts, I have self-harmed, I can't leave the house, I can't drive.
"And just generally I am completely confined to my own home and everything else just feels too much."
Anti-depressant drugs and psychological treatments, like cognitive behavioural therapy, help the majority of people.
But many don't respond to existing therapies and so some scientists are now exploring a new frontier - whether the immune system could be causing depression.
"I think we have to be quite radical," says Prof Ed Bullmore, the head of psychiatry at the University of Cambridge.
He's at the forefront of this new approach: "Recent history is telling us if we want to make therapeutic breakthroughs in an area which remains incredibly important in terms of disability and suffering then we've got to think differently."
The focus is on an errant immune system causing inflammation in the body and altering mood.
And Prof Bullmore argues that's something we can all relate to, if we just think back to the last time we had a cold or flu.
He said: "Depression and inflammation often go hand in hand, if you have flu, the immune system reacts to that, you become inflamed and very often people find that their mood changes too.
"Their behaviour changes, they may become less sociable, more sleepy, more withdrawn.
"They may begin to have some of the negative ways of thinking that are characteristic of depression and all of that follows an infection."
It is a subtle and yet significant shift in thinking. The argument is we don't just feel sorry for ourselves when we are sick, but that the chemicals involved in inflammation are directly affecting our mood.
Find out more
You can listen to The Inflamed Mind documentary on BBC Radio 4 at 21:00 BST and then here on iPlayer.
Inflammation is part of the immune system's response to danger. It is a hugely complicated process to prepare our body to fight off hostile forces.
If inflammation is too low then an infection can get out of hand. If it is too high, it causes damage.
And for some reason, about one-third of depressed patients have consistently high levels of inflammation. Hayley is one of them: "I do have raised inflammation markers, I think normal is under 0.7 and mine is 40, it's coming up regularly in blood tests."
There is now a patchwork quilt of evidence suggesting inflammation is more than something you simply find in some depressed patients, but is actually the cause of their disease. That the immune system can alter the workings of the brain.
whatever the result or none, I can link you into some FB groups which are run for and by Neurodoverse people Your tribe is waiting if and well you chose to engage!
As people are being helpful, I know I am not the only autistic here but I am an experienced advocate and peer supporter. Even been trained in autism as well as living with it for all my life lololol If there is anything I can offer to people....
Of course, that could be the result of drinking a lot of hard liquor, killing off all but the hardiest of gut flora.Their research has shown that people who are clinically depressed have less diversity in the microbiota in their gut than people who are not depressed, he said.
Worth getting checked out - could be all sorts of things that are making your feel tired, not just your mood.So constantly exhausted recently that it's clear my depression has returned.
/ when depressed I just want to sleep 24x7, I dont have thoughts of self harm or anything