Humanoid aliens. Evolution will work the same on every planet, and our body form is not the only practical one. There are some factors that can help get a species to space - binocular absorption of light around our visual spectrum, some sort of hands/tentacles to make and use tools, audible language that isn't limited by direct sight lines, living in air for access to heat-based energy. But these don't necessarily lead to something almost exactly human. And no cross-breeding hybrid children! Sex, sure, there are people who get jiggy with all sorts of un-people, just look at the Weird Sex thread.
Star Trek's "The Devil in the Dark" was one of the first times I saw a physically alien sentient being, and there were others in that series. (I know, TNG had the explanation lonely ancient aliens pansperming.) Live action telly and movie have some limits, but animated films and even more so written stories can dispense with that.