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Seeking Longer Lives; Slower Aging; Even Immortality

would u take a pill to live forever?

  • yes

    Votes: 8 42.1%

  • maybe

    Votes: 7 36.8%

  • no

    Votes: 3 15.8%

  • no, and would outlaw it

    Votes: 1 5.3%
  • Total voters
    19
Boe.jpg
 
JamesWhitehead said:
Yet pubes are oddly ageless. :rolleyes: ...
Click to expand...

If you're referring to persistence of presence, I agree.

If you're referring to pigmentation, I can assure you you're mistaken. :evil:
 
GNC said:
But what would you look like? A brain in a jar? Life spans may be extended, but will your overall health and vigour? Even active centenarians don't look like they did in their forties, never mind their twenties.
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Brain in a jar in a cave looking at the projections on the wall.
 
Libella Gene Therapeutics says it will administer volunteers with a gene therapy that it claims can reverse aging by up to 20 years, according to OneZero. Despite the fact that this is the first human trial of the treatment, the company is charging volunteers $1m to take part. In an effort to side-step the FDA, the trial will take place in Colombia.

The therapy will attempt to repair people’s telomeres, the caps on the end of our chromosomes that shorten as people get older. It’s long been thought that they play a role in aging, and efforts to extend telomeres in mice have shown that it can delay the signs of getting older and increase healthy lifespan, though it’s yet to be tested in humans.

https://singularityhub.com/2019/12/...its-first-human-trial-and-it-costs-1-million/
 
Tribble said:
Libella Gene Therapeutics says it will administer volunteers with a gene therapy that it claims can reverse aging by up to 20 years, according to OneZero. Despite the fact that this is the first human trial of the treatment, the company is charging volunteers $1m to take part. In an effort to side-step the FDA, the trial will take place in Colombia.

The therapy will attempt to repair people’s telomeres, the caps on the end of our chromosomes that shorten as people get older. It’s long been thought that they play a role in aging, and efforts to extend telomeres in mice have shown that it can delay the signs of getting older and increase healthy lifespan, though it’s yet to be tested in humans.

https://singularityhub.com/2019/12/...its-first-human-trial-and-it-costs-1-million/
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:rollingw:

There's really no end to rich people's stupidity and entitlement, is there?
 
Tribble said:
The therapy will attempt to repair people’s telomeres
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This has the capacity to go very, very wrong. One working definition of cancer (in an oncological research sense) is the absence of death at a cellular level. Great care & foresight will be needed here....

The concept of telomere flawed replication as a key (or even The) age-driver and the 'frayed ends' analogy are absolutely-riveting as biognostic narratives. But they may only be facets, not fabric.
 
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The indigenous Tsimane people of the Amazon region have remarkably low rates of cardiac and brain deterioration as they age - in fact, the lowest rates known.
Amazon Indigenous People May Hold a Key to Slowing Down Aging

Tsimane people are unique for their healthy brains that age more slowly.

A team of international researchers has found that the Tsimane indigenous people of the Bolivian Amazon experience less brain atrophy than their American and European peers. The decrease in their brain volumes with age is 70% slower than in Western populations. Accelerated brain volume loss can be a sign of dementia.

The study was published today (May 26, 2021) in the Journal of Gerontology, Series A: Biological Sciences and Medical Sciences.

Although people in industrialized nations have access to modern medical care, they are more sedentary and eat a diet high in saturated fats. In contrast, the Tsimane have little or no access to health care but are extremely physically active and consume a high-fiber diet that includes vegetables, fish, and lean meat. ...

The researchers note that the Tsimane have high levels of inflammation, which is typically associated with brain atrophy in Westerners. But their study suggests that high inflammation does not have a pronounced effect upon Tsimane brains.

According to the study authors, the Tsimane’s low cardiovascular risks may outweigh their infection-driven inflammatory risk, raising new questions about the causes of dementia. One possible reason is that, in Westerners, inflammation is associated with obesity and metabolic causes whereas, in the Tsimane, it is driven by respiratory, gastrointestinal, and parasitic infections. ...

The indigenous Tsimane people captured scientists’ — and the world’s — attention when an earlier study found them to have extraordinarily healthy hearts in older age. That prior study, published by the Lancet in 2017, showed that Tsimane have the lowest prevalence of coronary atherosclerosis of any population known to science and that they have few cardiovascular disease risk factors. The very low rate of heart disease among the roughly 16,000 Tsimane is very likely related to their pre-industrial subsistence lifestyle of hunting, gathering, fishing, and farming.
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FULL STORY:
https://scitechdaily.com/amazon-indigenous-people-may-hold-a-key-to-slowing-down-aging/

PUBLISHED REPORT:
Andrei Irimia, Ph.D, Nikhil N Chaudhari, M.S, David J Robles, M.A, Kenneth A Rostowsky et al.
The indigenous South American Tsimane exhibit relatively modest decrease in brain volume with age despite high systemic inflammation
The Journals of Gerontology: Series A, 2021; glab138
https://doi.org/10.1093/gerona/glab138

https://academic.oup.com/biomedgero...e-abstract/doi/10.1093/gerona/glab138/6280196
 
Xanatic* said:
Rich guy Bryan Johnson tries to stay young by swapping blood with his son. Also with his father for some reason. It costs 2 million dollars per go, so not for everybody.

https://www.bloomberg.com/news/arti...-aging-blood-transfusion-involves-dad-and-son
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There's definitely something in that idea. I remember hearing that an old person, receiving a transfusion from a young person, may heal a bit quicker. It's largely due to young blood retaining its properties - better platelet formation, better oxygen-transferring abilities, etc.
 
Maybe we should sleep In Michael Jackson’s hyperbaric oxygen chamber to live longer, or not ?
 
I think we should sleep in Tupperware boxes.
There have been some experiments on mice, which indicate blood from younger mice has beneficial effects. When blood transfusions were first attempted in the 1600s, people also feared such scenarios.
 
ramonmercado said:
The world’s first anti-aging drug will be tested on humans next year in trials that could result in people being able to live healthily well into their 120s.

Scientists now believe it is possible to stop people growing old as quickly and consign diseases such as Alzheimer’s and Parkinson’s to history.

Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the U.S. has now given the go-ahead for a trial to see if the same effects can be replicated in humans.

If successful, it will mean that a person in their 70s would be as biologically healthy as a 50-year-old. ...

http://news.nationalpost.com/health...t-you-live-more-than-120-years-in-good-health
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How metformin works. I've taken metformin since 2021, hopefully it's extending my lifespan as well as dealing with diabetes.

Since the 1990s, doctors have prescribed the drug metformin to treat type 2 diabetes, but scientists didn't fully understand how it worked.

Now, new research fills in one piece of the puzzle: Metformin triggers the body to expel glucose from the bloodstream into the intestines, where bacteria feed on the carbohydrate to make compounds that may help control blood sugar levels.

In the new study, published March 3 in the journal Communications Medicine, researchers calculated that metformin treatment increased how much glucose was released into the gut nearly fourfold. That seemed to boost the production of fatty compounds that help protect the gut and reduce inflammation.

https://www.livescience.com/health/...tformin-lowers-blood-sugar-animal-study-finds
 
Good video:

Today I'm talking about the four types of immortality found in organisms across the tree of life, and how these examples can help us understand treatments in human longevity. If animals can evolve to do it, can we engineer ourselves to do it too? Perhaps only time will tell.

0:00 Introduction
0:44 Negligible Senescence
1:14 Greenland Shark
2:33 Hydra
4:01 Why We Age
4:58 The Hayflick Limit
6:27 Telomeres
7:04 Lobsters
8:19 Whoops, Cancer (also stem cells)
9:39 The Evolution of Immortality
11:08 Olms Being Olms
11:57 Immortal Jellyfish (Negative Senescence)
14:22 Planaria (absolute freaks)
15:32 Clonal Colonies
18:11 Cryptobiosis (Tardigrades)
20:18 Cryogenic Freezing
21:07 Bryan Johnson
22:37 Qin Shi Huang, First Emperor of China
23:42 Bryan Johnson cont.
24:50 Outroduction

 
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